What's a historical setting that you'd like to see, but likely won't happen?
For me, I'd really love a game set in the wild west. And I think it could work despite what people always say. If they'd set it in the California Gold Rush, you could have San Francisco be one large city the game revolves around with plent of parkour centric level design, and then a bunch of wilderness and small towns set outside it. Similar to AC3.
Story wise, I'd say it's pretty obvious that the California Gold Rush was a huge opportunity to find a piece of eden and both Assassin's and Templars racing to expand influence in a quickly developing new society.
I've never understood why most people are so against it, but I'd certainly love to see it. Any offbeat settings you'd like to see one day?